Variation of miRNA target sites in the Human Genome

12 pages•Published: March 22, 2022

Brad V. Bellomo, Helen Piontkivska and Arvind K. Bansal

Abstract

MicroRNAs (miRNAs) are important regulators of gene expression in humans and many other organisms. Genetic variation in target sites potentially alters this regulation. Better understanding of patterns of nucleotide changes of these sites can provide new insights into human diseases such as cancer, bacterial and viral diseases. Studies of human variation of miRNA binding sites have been done before. However, we focus our study on miRNA-mRNA pairs that are known to be co-expressed. Unlike previous studies, this work considers combinations of several genetic variants, identifies those that are potentially evolutionary conserved, and considers how frequently alleles occur in the human population. New algorithm for matching the target sites has been described. Our findings confirm the putative functional significance of many alleles already reported in medical cancer-related literature, and suggest others not previously reported in literature. These alleles may be worth investigating further.

Keyphrases: indel, mirna, mirna target site, snp

In: Hisham Al-Mubaid, Tamer Aldwairi and Oliver Eulenstein (editors). Proceedings of 14th International Conference on Bioinformatics and Computational Biology, vol 83, pages 96-107.

Links:	https://easychair.org/publications/paper/sqS7
	https://doi.org/10.29007/fcl4

BibTeX entry

@inproceedings{BICOB2022:Variation_miRNA_target_sites,
  author    = {Brad V. Bellomo and Helen Piontkivska and Arvind K. Bansal},
  title     = {Variation of miRNA target sites in the Human Genome},
  booktitle = {Proceedings of 14th International Conference on Bioinformatics and Computational Biology},
  editor    = {Hisham Al-Mubaid and Tamer Aldwairi and Oliver Eulenstein},
  series    = {EPiC Series in Computing},
  volume    = {83},
  publisher = {EasyChair},
  bibsource = {EasyChair, https://easychair.org},
  issn      = {2398-7340},
  url       = {/publications/paper/sqS7},
  doi       = {10.29007/fcl4},
  pages     = {96-107},
  year      = {2022}}

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