Advances in Regenerative Medicine: from Bioengineered Human Skin Models to Clinical Therapies

EasyChair Preprint 12306

Abstract

Ongoing advancements in regenerative medicine, coupled with the development of tissue-engineered skin products, present new avenues for treating diseases with elusive permanent cures. Our laboratory has successfully engineered a fibrin-based human skin, demonstrating efficacy in permanent regenerative therapies. Through orthotopic grafting onto immunodeficient mice, we established a unique skin-humanized mouse model, enabling the study of various monogenic skin diseases. The model system has proven instrumental in testing gene therapy approaches for cell correction, particularly in the case of psoriasis, a chronic inflammatory condition. This development addresses the critical need for reliable humanized animal models in understanding disease pathogenesis and innovating therapeutic strategies.

Keyphrases: Bioengineered Human Skin Models, Clinical Therapies, regenerative medicine

@booklet{EasyChair:12306,
  author    = {Shakib Hassan},
  title     = {Advances in Regenerative Medicine: from Bioengineered Human Skin Models to Clinical Therapies},
  howpublished = {EasyChair Preprint 12306},
  year      = {EasyChair, 2024}}