CMOS-Based Biosensor Using Broadband Tunable Active-Inductor-Based VCO with γ-Dispersion for Detecting CTCs and Exosomes

EasyChair Preprint 7425

Abstract

In this paper, we propose a CMOS biosensor that can be extensively tuned by voltage control using an active inductor. biosensor is proposed. In order to detect circulating tumor cells (CTCs) and exosomes, a voltage-controlled oscillator (VCO) with active inductors is employed to operate at a wider frequency range with a chip area of 0.086 mm² including PAD, which is smaller than that of conventional circuits. To verify the operation of the proposed biosensor, electromagnetic (EM) simulation shows that the electric field extends to the cells on the interdigital capacitor (IDC) in the sensing area. Based on the simulation results, we conducted experiments on a prototype fabricated using the TSMC 65-nm standard process. The biosensor was found to vary from about 1.78-4.43 GHz with a power consumption of 39.0-45.8 mW. 2 μl of purified water was dropped onto the sensor multiple times and successfully detected water with an average frequency shift of 0.702 GHz. These results indicate that the proposed biosensor has the potential to detect biomarkers such as CTCs and exosomes.

Keyphrases: Active Inductor, Biosensors, CMOS, Circulating Tumor Cells (CTCs), Exosomes, Interdigital Capacitor (IDC)

@booklet{EasyChair:7425,
  author    = {Takuya Tsujimura and Shunya Murakami and Guowei Chen and Yuma Hayashi and Sora Kato and Akiyoshi Tanaka and Kiichi Niitsu},
  title     = {CMOS-Based Biosensor Using Broadband Tunable Active-Inductor-Based VCO with γ-Dispersion for Detecting CTCs and Exosomes},
  howpublished = {EasyChair Preprint 7425},
  year      = {EasyChair, 2022}}