Progress in Humanized Mouse and Rat Models for Advancing HIV Research: Transitioning from Traditional Approaches to Innovative Strategies

EasyChair Preprint 12523

Abstract

In the field of HIV research, humanized mouse and rat models have become indispensable tools, playing crucial roles as bridges between in vitro studies and clinical trials. This article explores the current landscape of these models, highlighting their pivotal contributions to investigating preventive and curative strategies against HIV infection and associated pathologies. The discussion encompasses various methodologies employed for the humanization of these animal models, addresses encountered challenges, and introduces emerging techniques that show promise in advancing HIV research. By examining the strengths and limitations of existing models, this article aims to steer researchers towards more effective strategies in the ongoing fight against HIV/AIDS. Human immunodeficiency virus (HIV) poses an ongoing global health challenge, prompting the continuous exploration of innovative therapeutic strategies. This study delves into the adoptive transfer of allogeneic gamma delta (γδ) T cells and its repercussions on HIV replication using a humanized mouse model. The research aims to unravel the potential risks and benefits associated with this therapeutic approach, with a specific focus on its effects on viral load, immune response, and overall host health.

Keyphrases: Humanized Mouse, Innovative Strategies, Rat Models

@booklet{EasyChair:12523,
  author    = {Liis Tammik},
  title     = {Progress in Humanized Mouse and Rat Models for Advancing HIV Research: Transitioning from Traditional Approaches to Innovative Strategies},
  howpublished = {EasyChair Preprint 12523},
  year      = {EasyChair, 2024}}