Synthesis, Characterization of New Formazan Derivatives and Study of Biological and Anticancer Activity

EasyChair Preprint 7976

Abstract

The aim of the research is the synthesis of formazan derivatives and the study of its biological activity and anticancer (breast cancer).The first step: reaction of the amino derivative 4-Methoxy-2-nitroaniline with Chloroacetyl Chloride to prepare the derivative (1), the second step: reaction of the derivative (1) with Hydrazine hydrate to prepare the derivative (2),the third step: the reaction of the derivative (2) with the Vanillin to prepare the Schiff base derivative (3), and the last step: included the reaction of the following amines (2-Amino benzimidazole, 3-Bromoaniline, 1-Phenol-2,3-dimethyl-4-aminopyrazolon-(5), 2-Amino-6-methoxybwnzothiazole) with sodium nitrite and hydrochloric acid to form diazonium salt which is reacted with Schiff base derivative (3) to prepare formazan derivatives (4-7). All the prepared derivatives were studied spectroscopically by means of a spectrum (FT-IR,¹H-NMR,¹³C-NMR).

Keyphrases: Anticancer activity, Formazan Derivatives, MCF-7, biological activity, breast cancer

@booklet{EasyChair:7976,
  author    = {Luay A. Khaleel and Shaimaa Adnan},
  title     = {Synthesis, Characterization of New Formazan Derivatives and Study of Biological and Anticancer Activity},
  howpublished = {EasyChair Preprint 7976},
  year      = {EasyChair, 2022}}