Synthesis and Characterization of Novel Highly Functionalized Thiophene Heterocycles

EasyChair Preprint 7639

Abstract

A series of novel ethyl 2-(2-chloroacetamido)-4-methyl-5-(arylcarbamoyl)thiophene-3-carboxylate derivatives have been synthesized starting from various ethyl 2-amino-5-methyl-4-(arylcarbamoyl)thiophene-3-carboxylate. Reaction of 3-oxo-N-arylbutanamide 1a-j with ethyl cyanoacetate and sulphur under reflux condition afforded ethyl 2-amino-5-methyl-4-(arylcarbamoyl)thiophene-3-carboxylate 2a-j derivatives. Further reaction of 2-amino thiophene derivatives 2a-j with chloroacetyl chloride in acetone using K₂CO₃ as base under atmospheric condition afforded novel highly functionalized Thiophene 3a-j heterocycles with excellent yields.

Keyphrases: Acetamide, Aminothiophene, Gewald’s methodology

@booklet{EasyChair:7639,
  author    = {Jaysinh Jadeja and Jayraj Jatiya and Mahesh Savant},
  title     = {Synthesis and Characterization of Novel Highly Functionalized Thiophene Heterocycles},
  howpublished = {EasyChair Preprint 7639},
  year      = {EasyChair, 2022}}