Design and Characterization of an Innovative Rodent Model, Human Skin and Immune System Humanized, for Investigating Skin Pathogen Infections

EasyChair Preprint 12302

Abstract

The human skin, serving as the primary barrier against pathogen transmission, is a pivotal focal point in infectious disease research. While rodent models have proven valuable for studying human-specific skin pathogens, the successful co-engraftment of human skin, autologous lymphoid tissues, and immune cells poses a persistent challenge. This study introduces the development of a groundbreaking human Skin and Immune System (hSIS)-humanized NOD-scid IL2Rγnull (NSG) mouse and Sprague–Dawley-Rag2tm2hera Il2rγtm1hera (SRG) rat models, involving the concurrent engraftment of full-thickness human fetal skin, autologous fetal lymphoid tissues, and autologous fetal liver-derived hematopoietic stem cells.

Keyphrases: Humanized rodent models, Immunodeficient mice, Skin infections

@booklet{EasyChair:12302,
  author    = {Rohit Mishra},
  title     = {Design and Characterization of an Innovative Rodent Model, Human Skin and Immune System Humanized, for Investigating Skin Pathogen Infections},
  howpublished = {EasyChair Preprint 12302},
  year      = {EasyChair, 2024}}