Phyre and PhyreRisk – Integrating genetic variant data with experimental and predicted protein structures and their complexes

EasyChair Preprint 15

Abstract

Phyre is a widely-used web server for tertiary protein structure prediction and modelling with over 80,000 distinct users per year and is part of the ELIXIR tools resource. We are developing 3D models for predicted complexes by integrating tertiary models, the experimental structure of complexes and protein-protein interaction data. A new resource, PhyreRisk, is being developed which will enable users to map protein missense variants onto experimental and predicted tertiary structures and complexes. See www.sbg.bio.ic.ac.uk/~phyre2 and phyrerisk.bc.ic.ac.uk

Keyphrases: Integrative bioinformatics, genetic variants, protein structure prediction

@booklet{EasyChair:15,
  author    = {Lawrence A Kelley and Alessia David and Sirawit Ittisoponpisan and Stefans Mezulis and Tochukwu C Ofoegbu and Devlina Chakravarty and Petras J Kundrotas and Ilya A Vakser and Michael Sternberg},
  title     = {Phyre and PhyreRisk – Integrating genetic variant data with experimental and predicted protein structures and their complexes},
  doi       = {10.29007/k83b},
  howpublished = {EasyChair Preprint 15},
  year      = {EasyChair, 2018}}