Synthesis and Characterization of Novel Highly Functionalized Indole Derivatives.

EasyChair Preprint 7668

Abstract

A series of novel (Z)-3-(3-((3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)-1H-indol-1-yl)-N-arylpropanamide 7a-j have been synthesized starting from various 3-(3-formyl-1H-indol-1-yl)-N-arylpropanamide 5a-j. Synthesis of various 5a-j were prepared by reacting 1H-indole-3-carbaldehyde with 3-chloro-N-arylpropanamide 2a-j and K₂CO₃ as a base in acetone under room temperature. Further reaction of 5a-j with 5-methyl-2,4-dihydro-3H-pyrazol-3-one 6 in the presence of alcohol was yielded novel highly functionalized indole 7a-j with excellent yields.

Keyphrases: 3-methyl-5-pyrazolone, Vilsmeier-Haack reaction, indole

@booklet{EasyChair:7668,
  author    = {Jayraj Jatiya and Jaysinh Jadeja and Anilkumar Patel and Mahesh Savant},
  title     = {Synthesis and Characterization of Novel Highly Functionalized Indole Derivatives.},
  howpublished = {EasyChair Preprint 7668},
  year      = {EasyChair, 2022}}